Reconstructing contact network parameters from viral phylogenies

Reconstructing contact network parameters from viral phylogenies

Models of the spread of disease in a population often make the simplifying assumption that the population is homogeneously mixed, or is divided into homogeneously mixed compartments. However, human populations have complex structures formed by social contacts, which can have a significant influence on the rate of epidemic spread. Contact network models capture this structure by explicitly repre...

Reconstructing and Using Phylogenies

Reconstructing phylogenies of metastatic cancers

Program for Evolutionary Dynamics, Harvard University, Cambridge, MA, USA. IST (Institute of Science and Technology) Austria, Klosterneuburg, Austria. The David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Department of Mathematic...

Recommende Sources Reconstructing Molecular Phylogenies

Phylogeny, the tree of life Essential molecular mechanisms as replication and gene expression were found to be similar among the organisms studied so far. This favors the idea that all present day living organisms have evolved from a common ancestor. The relationship is called phylogeny and is represented by a phylogenetic tree.

New approaches for reconstructing phylogenies from gene order data

We report on new techniques we have developed for reconstructing phylogenies on whole genomes. Our mathematical techniques include new polynomial-time methods for bounding the inversion length of a candidate tree and new polynomial-time methods for estimating genomic distances which greatly improve the accuracy of neighbor-joining analyses. We demonstrate the power of these techniques through a...